Comparative analysis of the hemostasis system of cancer patients with thrombotic complications
DOI:
https://doi.org/10.34287/MMT.2(49).2021.11Abstract
Surgical treatment of female genital cancer remains a rather difficult task in gynecological practice due to the possibility of thrombotic complications. It is important to study the features of hemostasis in such patients for the practical application of this knowledge. The aim of the study was to scientifically substantiate the features of hemostasis in patients with female genital cancer. Study materials: 103 patients with genital cancer who were treated.
The purpose of the study. Coagulogram, colorimetry, others. Results of the research. As a result of a blood test, it was found that the initial level of hemoglobin in patients with thrombotic complications after surgery decreased by 12%, in patients without thrombotic complications – by 14%. The average platelet count in patients with thrombotic complications decreased by 11,50%, in patients without thrombotic complications – 8,12%. The level of leukocytes in patients with thrombotic complications – increased by 21,05%, in patients without thrombotic complications – 30,30%. In the study of hemostasis, it has been found that surgery in patients with female genital cancer causes a pronounced activation of the hemostasis system, especially in patients with thrombotic complications. In patients with thrombotic complications there is a more pronounced activation of intravascular coagulation on the background of a significant decrease in the level of antigen III than in patients without thrombotic complications. The level of fibrinogen in patients with thrombotic complications in the preoperative period was significantly higher by 16,3% than in patients without thrombotic complications; there was a decrease in fibrinogen levels in the early postoperative period; from the third day after surgery, fibrinogen levels increased in patients without thrombotic complications. There was also a significant reduction in activated partial thromboplastin time in patients with thrombotic complications. The number of soluble complexes of fibrin monomers increased to higher values in patients with thrombotic complications. Conclusion. In the study of hemostasis, it has been found that surgery in patients with female genital cancer causes marked activation of the hemostasis system, especially in patients with thrombotic complications.
References
Rak v Ukraїnі, 2019–2020 rr. Bjuleten' Nacіonal'nij Kancer – reєstru № 22. Harakteris- tiki onkoepіdemіologіchnogo procesu: stan onko- logіchnoї dopomogi [Іnternet]. 2020. [citovano 20 Sіch 2021]. Dostupno: http://www.ncru.inf.ua/ publications/BULL_22/PDF/tytul.pdf.
Samohvalova OO, Turchak OV, Tkalja JuG. Klіnіchnі ta morfologіchnі osoblivostі puhlin zo- vnіshnіh statevih organіv u zhіnok, shho prohodili lіkuvannja v Nacіonal'nomu іnstitutі raku. Klі- nіchna onkologіja. 2019; 34 (2): 1-4. DOI: 10.32471/ clinicaloncology.2663-466X.39.22668.
Kupets R, Giede KC, Power P, Agrawal A, Executive of the Society of Gynecologic Oncology of Canada. The investigations required before referring a patient to a gynaecologic oncologist. J Obstet Gynaecol Can. 2016; 38 (2): 164–7.
Shakar'janc GA, Budanova DA, Lobastov KV, Habarova NV, Kirichenko JuJu, Belenkov JuN. Lechenie i vtorichnaja profilaktika venoznyh trombojembolicheskih oslozhnenij u onkologicheskih bol'nyh. Kardiologija. 2020; 60 (3): 71–79. DOI: 10.18087/cardio.2020.3.n904.
Skorbach EI, Shherbina IN, Lazurenko VV, Mercalova OV. Postgisterjektomicheskie narushenija i profilaktika ih razvitija. Mezhdunarodnyj medicinskij zhurnal. 2011; 17 (2): 27–31.
Kasjuk AA. Retrospektivnyj analiz antikoaguljantnoj profilaktiki u onkologicheskih pacientov, umershih v posleoperacionnom periode ot trombojembolii legochnoj arterii. Novosti hirurgii. 2010; 18 (1): 75–79.
Dobrova VЄ, Zupanec' KO, Mіsjur'ova SV, Mazur NS. Zabezpechennja jakostі gematologіchnih doslіdzhen' na prikladі valіdacії metodiki viznachennja koncentracіja gemoglobіnu v bіologіchnih rіdinah gemoglobіncіanіdnim metodom. Sistemi obrobki іnformacії. 2015; № 2 (127):104–107.
Kabat GC, Kim MY, Manson JE, Lessin L, Lin J, Wassertheil-Smoller S, et al. White blood cell count and total and cause-specific mortality in the women’s health initiative. Am J Epidemiol. 2017; 186 (1): 63–72.
Vorob'eva AI, redaktor. Prakticheskaja koagulologija. Moskva: «Prakticheskaja medicina»; 2010. 192 p.
Gmurman VE. Teorija verojatnostej i matematicheskaja statistika. Moskva: Vyssh.shk.; 2003. 479 p.
