The ocular cardiac reflex effect study on cardiac hemodynamic parameters in healthy young mans
DOI:
https://doi.org/10.34287/MMT.1(40).2019.3Abstract
Purpose of the study. Investigate changes of cardiac hemodynamic parameters caused by ocular cardiac reflex triggering in healthy men’s in youthful age.
Material and methods. 120 healthy male volunteers in youthful age were examined. The mean age was (19,2 ± 0,93 years). For ocularcardiac reflex (OCR) triggering we used a patented model «Device for dosed compression effects on the eyeballs» and «The method of ocular cardiac reflex triggering». On the basis of the obtained parameters of systolic (SBP) and diastolic (DBP) blood pressure, by arithmetic operations, pulse pressure (PP) and average flow pressure (AFP) and integrative parameters of cardiohemodynamics (CHD) – systolic blood volume (SBV), minute blood flow volume (MBFV), volumetric blood flow rate (V), total peripheral resistance (TPR) were determined.
Results. Three main types of cardiovascular system response on OCR triggering were identified. The first type – hypertensive (n = 30 (25%) of the total number of examined subjects) was characterized by a significant (p < 0,05) increase in heart rate, SBP, DBP, PP, AFP and other integrative parameters of CHD. The second, hypotonic type of the response (62 subjects; 51,7%) was characterized by a significant (p < 0,05) decrease in SBP, DBP, PP, AFP. Patients with third, dystonic type, of response (n = 28 (23,3%) of the total number examined subjects) showed significant bilateral changes of blood pressure parameters in a nonlinear dependence of compression power on the eyeballs. Determination CHD parameters directly after and 3 and 5 minutes after decompression of the air in the compression device we enabled to determine the subtype of the mobility of the nervous centers as a feature that complements the basic type. The subtype of normal mobility was revealed in 63,3% (n = 19) of subjects with the main hypertensive type of response, 69,3% (n = 43) of subjects with the main hypotonic and 60,7 % (n = 17) with the main dystonic type of response of the cardiovascular system. The inert subtype in the mobility of the cardiovascular system were identified in 36,7% (n = 11) individuals with hypertension is the main type of response, at 30,7% (n = 19) of individuals with primary hypotonic type of response and 39,3 % (n = 11) – distancing. The obtained typological changes in blood pressure parameters caused by OCR triggering allowed to reveal predisposition to hypertension, hypotension, dystonia and to predict the development of hypertension in patients with hypertensive type of response usin appropriate primary prevention changes in life style. The highest risk of hypertension development may be in persons with hypertensive inert type of reaction of the system of regulation of blood pressure on OCR triggering. Further studies are being conducted to confirm this assumption.
References
Barrera L. Comment on the 2017 ACC/AHA interventions for high blood pressure with particular reference to middleand low-income countries. Eur. J. Prev. Cardiol., 2018, vol. 25, № 9, pp. 902–905.
Mancusi C., Losi M. A., Izzo R. et al. Higher pulse pressure and risk for cardiovascular events in patients with essential hypertension: The Campania Salute Network. Eur. J. Prev. Cardiol., 2017, vol. 25, № 3, pp. 235–243.
Kapadia S. Trends in cardiovascular risk profiles. Cleve Clin. J. Med., 2017, vol. 84, Suppl. 4, pp. 6–9.
Cifu A. S., Davis A. M. Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. JAMA, 2017, vol. 318, № 21, pp. 2132–2134.
European Society of Hypertension and of the European Society of Cardiology. 2013 ESH/ESC Guidelines forthe management ofarterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur. Heart J., 2013, vol. 34, № 28, pp. 2159–2219.
Katsi V., Kallistratos M. S., Kontoangelos K. et al., Arterial Hypertension and Health-Related Quality of Life. Front. Psychiatry. 2017, vol. 8, 270. doi: 10.3389/fpsyt.2017.00270.
Kushakovskiy M. S. Essential hypertension. SPb, 1995, (in Russian).
Shulutko B. I. Arterial hypertension. SPb, 2000, (in Russian).
Sudakov K. V. The development of the theory of functional systems in the scientific school of P. K. Anokhin. Elektronnoye periodicheskoye izdaniye «Vestnik Mezhdunarodnoy akademii nauk, Russkaya sektsiya», 2011, vol. 1, pp. 1–5, (in Russian).
Sudakov K. V. Functional systems. Moskva, Izdatelstvo RAMN, 2011, (in Russian).
Veyn A. M. Vegetative disorders. Clinic. Diagnostics. Treatment. Moskva, Meditsinskoye informatsionnoye agentstvo, 1998, (in Russian).
Bazarny V. F. Vision in children. Development problems. Novosibirsk, Nauka, 1991, (in Russian).
Palamarchuk O. I. Device for dosed compression influence on the eyeballs]. Patent UA, № 100031, 2015, (in Ukrainian).
Starr. I. Clinical tests of simple method of estimating cardiac stroke volume from blood pressure and age. Circulation., 1954, vol. 9, № 2, pp. 664–681.
Tkachenko B. I. Basic human physiology. SPb, 1994, vol. 1, p. 244, (in Russian).
Palamarchuk O. I. Method of oculo-cardiac reflex type determining. Patent UA, № 98362, 2015, (in Ukrainian).
Human Experimentation: Code of Ethics of W. M. A. Br. Med. J., 1964, vol. 2 (5402), p. 177.
