Healing of diabetic ulcers in conditions of biological stimulation of reparation
DOI:
https://doi.org/10.34287/MMT.2(41).2019.23Abstract
Purpose of study. The repertory effect evaluation of autologous platelet-rich plasma in the treatment of patients with diabetic foot in stage 2.
Materials and methods. The study included 32 patients with diagnosisof diabetic foot in stage 2. At the time of inclusion in the study, all patients had a defect of the skin and subcutaneous fat on the foot, measuring 3–6 cm2, which was not corrected by traditional methods for 3–4 months. The comparison group consisted of 18 patients (56,25%) who received standard therapy. The study group consisted of 14 patients (43,75%), to whom standard therapy was supplemented by local serial administration of autologous platelet-rich plasma. To assess the effectiveness of the therapy, the area of the ulcerative defect was measured before manipulation, as well as at 1 week intervals until the ulcer was completely healed.
Results. Our experience with autologous platelet-rich plasma in the treatment of patients with diabetic foot in stage 2 demonstrated the effectiveness of this technique. A progressive, significant (p < 0,01) decrease in the area of the ulcerative defect starting from the 14th day was noted. When using platelet-rich plasma, we managed to achieve complete healing of diabetic ulcers in 64,2% of patients on day 35 and in 100% of patients on day 42.
Conclusion. Local administration of an autologous platelet-rich plasma allows the complete healing of diabetic ulcers in stage 2 with an area of 3–6 cm2 for 6 weeks.
References
Abredari H, Bolourchifard F, Rassouli M et al. Health locus of control and self-care behaviors in diabetic foot patients. Med J Islam Repub Iran. 2015 Oct 26; 29: 283. eCollection 2015. PubMed PMID: 26913246; PubMed Central PMCID: PMC4764266.
Kadam D. Microsurgical Reconstruction of Plantar Ulcers of the Insensate Foot. J Reconstr Microsurg. 2016; 32 (5): 402–410. DOI: 10.1055/s-0036-1579536
Hicks CW, Selvarajah S, Mathioudakis N et al. Burden of Infected Diabetic Foot Ulcers on Hospital Admissions and Costs. Ann Vasc Surg. 2016; 33: 149–158. DOI: 10.1016/j.avsg.2015.11.025
Andrews KL, Houdek MT, Kiemele LJ. Wound management of chronic diabetic foot ulcers: from the basics to regenerative medicine. Prosthet Orthot Int. 2015; 39 (1): 29–39. DOI: 10.1177/0309364614534296.
Zhang Z, Lv L. Effect of local insulin injection on wound vascularization in patients with diabetic foot ulcer. Exp Ther Med. 2016; 11 (2): 397–402. DOI: 10.3892/etm.2015.2917
Picard F, Hersant B, Bosc R, Meningaud JP. The growing evidence for the use of platelet-rich plasma on diabetic chronic wounds: A review and a proposal for a new standard care. Wound Repair Regen. 2015; 23 (5): 638–643. DOI: 10.1111/wrr.12317.
Usenko OY, Petrushenko VV, Savolyuk SI, Radyoga YV, Grebenyuk DI. Еxperimental estimation of the local application efficacy of biological stimulator for the soft tissues reparation in treatment of chronic gastric ulcers. Klinichna khirurhiya. 2016; 9: 62-65.
Usenko OY, Radyoha YV, Grebeniuk DI, Stukan OK. Combination of cells technologies and minsiinvasive surgery in the treatment of chronic gastric ulcer. Klinichna khirurhiya.. 2015; 10: 25-28.
