Abdominal Sepsis and Peritonitis: discussion and unsolved questions
DOI:
https://doi.org/10.34287/MMT.2(41).2019.30Abstract
Abdominal sepsis (AS) is one of the most severe complications in abdominal surgery. Mortality from the AS according to various data can reach up to 80–90% depending on the etiology, peculiarities of pathogenesis and comorbidities. Purpose of the study is to determine the current state of the problem of abdominal sepsis, to identify problems and discussion issues and to outline possible perspectives for their solution. AS remains one of the important problems of modern urgent abdominal surgery, and ii is characterized by a large variety of etiological factors and polymorphism of the clinical picture. Changing the paradigm of sepsis (Sepsis-1, 2, 3) requires correction of treatment-diagnostic approaches in patients with acute abdominal surgery. Existing methods of diagnosing and treating abdominal sepsis are not effective enough, and therefore there is a need to improve them and develop new, adequate therapeutic approaches.
References
Rhodes A, Evans LE, Alhazzani W et al. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med. 2017; 43 (3):1–74. DOI: 10.1007/s00134-017-4683-6.
Reinhart K, Daniels R, Kissoon N et al. Recognizing sepsis as a global health priority – a WHO resolution. N Engl J Med. 2017; 377 (5): 414–417. DOI: 10.1056/NEJMp1707170.
Cortés-Puch I, Hartog CS. Opening the debate on the new sepsis definition change is not necessarily progress: revision of the sepsis definition should be based on new scientific insights. Am J Respir Crit Care Med. 2016; 194 (1): 16–18. DOI: 10.1164/ rccm.201604-0734ED.
Boldingh QJ, de Vries FE, Boermeester MA. Abdominal sepsis. Curr Opin Crit Care. 2017; 23 (2): 159–166. DOI: 10.1097/MCC.0000000000000388.
Churpek MM, Snyder A, Han X et al. qSOFA, SIRS, and early warning scores for detecting clinical deterioration in infected patients outside the ICU. Am J Respir Crit Care Med. 2017; 45 (10): 1677–1682. DOI: 10.1164/rccm.201604-0854OC.
Sartelli M, Catena F, Ansaloni L et al. Complicated intra-abdominal infections world wide: the definitive data of the CIAOW Study. World J Emerg Surg. 2014; 9: 37–45. DOI: org/10.1186/1749-7922-9-37.
Simpson SQ. Diagnosing sepsis: a step forward, and possibly a step back. Ann Transl Med. 2017; 5 (3): 55–61. DOI: 10.21037/atm.2017.01.06.
Simpson SQ. SIRS in the Time of Sepsis-3. Chest. 2018; 153 (1): 34–38. DOI: 10.1016/j. chest.2017.10.006.
Sprung CL, Schein RMH, Balk RA. To SIRS with love – an open letter. Crit Care Med. 2017; 45 (4): 736–738. DOI: 10.1097/ CCM.0000000000002156.
Townsend SR, Rivers E. Definitions for sepsis and septic shock.JAMA. 2016; 316 (4): 457–458. DOI: 10.1001/jama.2016.6374.
Sprung CL, Trahtemberg U. What definition should we use for sepsis and septic shock? Crit Care Med. 2017; 45 (9): 564–1567. DOI: 10.1097/ CCM.0000000000002544.
Makam AN, Nguyen OK. Clinical criteria to identify patients with sepsis. JAMA. 2016; 316 (4): 453. DOI: 10.1001/jama.2016.6407.
Acharya A, Markar SR, Ni M, Hanna GB. Biomarkers of acute appendicitis: systematic review and cost-benefit trade-off analysis. Surg Endosc. 2017; 31 (3): 1022–1031. DOI: 10.1007/ s00464-016-5109-1.
Bermejo-Martin JF, Martín-Fernandez M, Almansa R. Pre-sepsis: a necessary concept to complete the SEPSIS-3 picture? J Crit Care. 2017; 44: 148. DOI: 10.1016/j.jcrc.2017.10.041.
Sartelli M, Chichom-Mefire A, Labricciosa FM et al. The management of intraabdominal infections from a global perspective: 74 2017 WSES guidelines for management of intraabdominal infections. World J Emerg Surg. 2017; 12: 29. DOI: 10.1186/s13017-017-0141-6.
Sartelli M, Catena F, Abu-Zidan FM et al. Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference. World J Emerg Surg. 2017; 4 (12): 22. DOI: 10.1186/s13017-017-0132-7.
Leppäniemi A, Kimball EJ, DeLaet I et al. Management of abdominal sepsis – a paradigm shift? Anaesthesiol Intensive Ther. 2015; 47 (4): 400–408. DOI: 10.5603/AIT.a2015.0026.
Sydorchuk R, Fomin P, Sydorchuk L et al. Gut microflora, microbial endotoxin, and mitric oxide form a vicious circle an acute enteral dysfunction syndrome: welcoming abdominal sepsis. Infection. 2015; 43 (1): S30.
Sartelli M, Abu-Zidan FM, Catena F et al. Global validation of the WSES sepsis severity score for patients with complicated intra-abdominal infections: a prospective multicenter study (WISS study). World J Emerg Surg. 2015; 10: 61. DOI: 10.1186/s13017-015-0055-0.
Henning DJ, Puskarich MA, Self WH et al. An emergency department validation of the SEP-3 sepsis and septic shock definitions and comparison with 1992 consensus definitions. Ann Emerg Med. 2017; 70 (4): 544–552. DOI: 10.1016/j. annemergmed.2017.01.008.
Fomin PD, Sydorchuk RI, Solovei YM, Solovei MM, Bazelyuk OM. Serum cholesterol acts as a metabolic marker for abdominal sepsis. Infection, 2015; vol. 43 (1): S32–33.
Raith EP, Udy AA, Bailey M et al. Prognostic accuracy of the SOFA score, SIRS criteria, and qSOFA score for in-hospital mortality among adults with suspected infection admitted to the intensive care unit. JAMA. 2017; 317 (3): 290–300. DOI: 10.1001/jama.2016.20328.
Freund Y, Lemachatti N, Krastinova E et al. Prognostic accuracy of Sepsis-3 criteria for inhospital mortality among patients with suspected infection presenting to the emergency department. JAMA. 2017; 317 (3): 301–308. DOI:10.1001/ jama.2016.20329.
Singer M, Deutschman CS, Seymour CW et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016; 315 (8): 801–810. DOI:10.1001/jama.2016.0287.
Sydorchuk A, Sydorchuk R, Fomin P, Sydorchuk L, Sydorchuk I. Bacterial endotoxin significantly deteriorate consequences of experimental liver injury through «explosion» of cytokines. United European Gastroenterology Journal. 2016; 4 (5S): А 160.
Kirkpatrick AW, Coccolini F, Ansaloni L et al. Closed Or Open after Source Control Laparotomy for Severe Complicated Intra-Abdominal Sepsis (the COOL trial): study protocol for a randomized controlled trial. World J Emerg Surg. 2018; 13: 26. DOI: 10.1186/s13017-018-0183-4.
Salamone G, Licari L, Guercio G et al. Vacuum-Assisted Wound Closure with MeshMediated Fascial Traction Achieves Better Outcomes than Vacuum-Assisted Wound Closure Alone: A Comparative Study. World J Surg. 2018; 42 (6): 1679–1686. DOI: 10.1007/s00268-017-4354-3.
Liu VX, Fielding-Singh V, Greene JD et al. The timing of early antibiotics and hospital mortality in sepsis. Am J Respir Crit Care Med. 2017; 196 (7): 856–863. DOI: 10.1164/rccm.201609-1848OC.
Whiles BB, Deis AS, Simpson SQ Increased time to initial antimicrobial administration is associated with progression to septic shock in severe sepsis patients. Crit Care Med. 2017; 45 (4): 623–629. DOI: 10.1097/CCM.0000000000002262.
Sartelli M, Kluger Y, Ansaloni L et al. Raising concerns about the Sepsis-3 definitions. World J Emerg Surg. 2018; 13: 6–17. DOI: org/10.1186/s13017-018-0165-6.