Use of metabolites, metabolithotropic agents and nutritional supplements in sports and sports medicine: a modern view on the problem
DOI:
https://doi.org/10.34287/MMT.4(59).2023.10Abstract
Aim. The purpose of this study was to conduct an up-to-date semantic analysis of the results of our own research and literature data on the medical and pharmacological characteristics of metabolites, metabolitotropic agents and nutritional supplements, the peculiarities of their use in sports practice and sports medicine.
Materials and methods. This study used bibliosemantic, analytical, logical, and generalization methods. The life sciences and biomedical information bibliographic databases MEDLINE, EMBASE, Medline (PubMed), Web of Science, and Cochrane Central were searched to find publications in English that matched the research keywords. The authors carried out an independent search and selection of articles, assessment of the quality of the data, compliance of the presentation and interpretation with the main idea of the study, with the formation of the final list of references.
Results. Based on the analysis of modern literature data and the results of our own studies, a generalized medical and pharmacological characteristic of metabolite agents, metabolitotropic drugs and nutritional supplements that can influence the main and compensatory mechanisms of macroergic phosphates production under the influence of physical activity is presented. The mechanisms of action, indications for use and main side effects of drugs and food additives based on ATP, malate, succinate, citrate, pyruvate, carnitine, carnosine, etc. are presented.
Conclusions. Semantic analysis data indicate that an urgent problem for sports medicine physicians and pharmacologists is the development and use of metabolites, metabolitotropic agents and nutritional supplements, as well as approaches to their rational combination to improve energy metabolism, replenish ATP reserves in the body that will help ensure the intensity muscular activity and simultaneously protect target organs.
References
Orchard JJ, Maddocks D, Carneiro E, Orchard JW. A review of legal, ethical, and governance issues for team doctors. Clin J Sport Med. 2022;32(3):24855. doi: 10.1097/JSM.0000000000000986
Gunina LM, Shustov YB, Belenichev IF, Vysochina NL, Golovashchenko RV, Morozova OV. Specialized nutrition for athletes: evaluation of ergogenic action using the principles of evidence-based medicine. Pharmacia. 2022;69(1):37-44. doi: 10.3897/pharmacia.69.e76599
Abbey EL, Wright CJ, Kirkpatrick CM. Nutrition practices and knowledge among NCAA Division III football players. J Int Soc Sports Nutr. 2017;14:1322. doi: 10.1186/s12970-017-0170-2
Baltazar-Martins G, de Souza DB, Aguilar-Navarro M, Muñoz-Guerra J, Plata MD, Del Coso J. Prevalence and patterns of dietary supplement use in elite Spanish athletes. J Int Soc Sports Nutr. 2019;16(1):е30. doi: 10.1186/ S12970-019-0296-5
Greg A, Alan MN. Statistical methods for assessing measurement error (reliability) in variables relevant to sports medicine. Sports Med. 1998;26(4):21738. doi: 10.2165/00007256-199826040-00002
Otten JJ, Hellwig JP, Meyers LD, editors. Dietary reference intakes: The essential guide to nutrient requirements. Washington, DC: The National Academies Press. 2006 [cited 2023, Jun 28]. Available from: http://nap. edu/openbook.php?record_id=11537
Thomas DT, Erdman KA, Burke LM. Position of the Academy of Nutrition and Dietetics, Dietitians of Canada, and the American College of Sports Medicine: Nutrition and Athletic Performance. J Acad Nutr Diet. 2016;116(3):50128. doi: 10.1159/000345862
Belenichev IF, Chernii VI, Kolesnik YM, Pavlov SV. [Rational neuroprotection]. Donetsk: ID Zaslavskii; 2009. Russian.
Close GL, Hamilton DL, Philp A, Burke LM, Morton JP. New strategies in sport nutrition to increase exercise performance. Free Radic Biol Med. 2016;98:144-58. doi: 10.1016/j.freeradbiomed.2016.01.016
Belenichev I, Gorchakova N, Kuchkovskyi O, Ryzhenko V, Varavka I, Varvanskyi P, et al. Principles of metabolithotropic therapy in pediatric practice. Clinical and pharmacological characteristics of modern metabolithotropic agents (part 1). Phytotherapy. Journal. 2022;3:6-26. doi: 10.33617/2522- 9680-2022-3-6
Ahmad NS, Abdul Aziz A, Kong, KW, Hamid MSA, Cheong JPG, Hamzah SH. Dose-response effect of tualang honey on postprandial antioxidant activity and oxidative stress in female athletes: A pilot study. J Altern Complement Med. 2017;23(12):989-95. doi: 10.1089/acm.2017.0129
Mazur I, Belenichev I, Kucherenko L, Bukhtiyarova N, Puzyrenko A, Khromylova O, et al. Antihypertensive and cardioprotective effects of new compound 1-(β-phenylethyl)-4-amino-1,2,4-triazolium bromide (Hypertril). Eur J Pharmacol. 2019;853:336-44. doi: 10.1016/j.ejphar.2019.04.013
Belenichev IF, Cherniy VI, Nagornaya EA, Bukhtiyarova NV, Kucherenko V. [Neuroprotection and Neuroplasticity]. Kiev: Logos; 2015. Russian.
Abel T, Knechtle B, Perret C, Eser P, von Arx P, Knecht H. Influence of chronic supplementation of arginine aspartate in endurance athletes on performance and substrate metabolism ‒ a randomized, double-blind, placebo-controlled study. Int J Sports Med. 2005;26(5):344-9. doi: 10.1055/s- 2004-821111
An D, Zeng Q, Zhang P, Ma Z, Zhang H, Liu Z, et al. Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice. Redox Biol. 2021;46:102088. doi: 10.1016/j.redox.2021.102088
Xu G, Yuan Y, Luo P, Yang J, Zhou J, Zhu C, et al. Acute succinate administration increases oxidative phosphorylation and skeletal muscle explosive strength via SUCNR1. Front Vet. Sci. 2022;8:808863. doi: 10.3389/ fvets.2021.808863
Burke LM. Practical issues in evidence-based use of performance supplements: supplement interactions, repeated use and individual responses. Sports Med. 2017;47(Suppl. 1):79-100. doi: 10.1007/s40279-017-0687-1
Hunter GR, Fisherm G, Neumeier WH, Carter SJ, Plaisance EP. Exercise training and energy expenditure following weight loss. Med Sci Sports Exercise. 2015;9:1950-7. doi: 10.1249/MSS.0000000000000622
Hunina LM, Ataman YO, Belenichev IF, Voitenko VL, Nosach OV. Laboratornyi monitoring i netrytyvno-metabolichna pidtrymka protsesu pidhotovky sportsmeniv [Laboratory monitoring and nutritional and metabolic support of the training process of athletes]. Sumy: SumDU; 2023. Ukrainian. https:// essuir.sumdu.edu.ua/bitstream-download/123456789/91724/3/Hunina_nu- trytyvno_metabolichna_pidtrymka.pdf
Belenichev IF, Aliyeva OG, Bukhtiyarova NV, Popazova OO, Ryzhenko VP. Positive Pharmacological Modulation of Hsp70 in Recovery of Brain Energy Metabolism in Various Models of Cerebral Ischemia. Biol Life Sci Forum. 2022;20(1):24. doi: 10.3390/IECBM2022-13511
Anders JPV, Neltner TJ, Smith RW, Keller JL, Housh TJ, Daugherty FJ, et al. The effects of phosphocreatine disodium salts plus blueberry extract supplementation on muscular strength, power, and endurance. J Int Soc Sports Nutr. 2021;18(1):60. doi: 10.1186/s12970-021-00456-y
Wu Y, Liu H, Wang X. Cardioprotection of pharmacological postconditioning on myocardial ischemia/reperfusion injury. Life Sci. 2021;264:118628. doi: 10.1016/j.lfs.2020.118628
Blomstrand E, Mooren FC, Krüger K, Kavazis AN, Quindry JC, Senchina DS, et al. Consensus statement immunonutrition and exercise. Exerc Immunol Rev. 2017;23:8-50.
Shu J, Shi J, Gu Y, Deng L, Zhao C, Wu C, et al. Levocarnitine regulates the growth of angiotensin II-induced myocardial fibrosis cells via TIMP-1. Open Life Sci. 2023;18(1):20220554. doi: 10.1515/biol-2022-0554
Emran T, Chowdhury NI, Sarker M, Bepari AK, Hossain, M., Rahman GMS, et al. L-carnitine protects cardiac damage by reducing oxidative stress and inflammatory response via inhibition of tumor necrosis factor-alpha and interleukin-1beta against isoproterenol-induced myocardial infarction. Biomed Pharmacother. 2021;143:112139. doi: 10.1016/j.biopha.2021.112139
Belenichev IF, Vizir VA, Mamchur VI, Kuriata OV. [Place of tiotriazoline in the gallery of modern metabolitotropic medicines]. Zaporozhye Med J. 2019;21(1):119-28. Russian. doi: 10.14739/2310-1210.2019.1.155856
Jin CL, Ye JL, Yang J, Gao CQ, Yan HC, Li H.C, et al. mTORC1 mediates lysine-induced satellite cell activation to promote skeletal muscle growth. Cells. 2019;8(12):1549. doi: 10.3390/cells8121549
Belenichev IF, Reznichenko YG, Reznichenko NY, Ryzhenko OI. [Perinatal lesions of the nervous system]. Zaporozhye: Prosvita; 2020. Russian.
Castell LM, Stear SJ, Burke LM, editors. Nutritional supplements in sport, exercise and health: An A-Z Guide. London: Routledge; 2015. doi: 10.4324/9781315772509
Belenichev IF, Nagornaya EA, Gorbacheva SV, Gorchakova NA, Bukhtiyarova NV. [Thiol-disulfide system: role in endogenous cytoand organoprotection, pathways of pharmacological modulation]. Kyiv: Euston Publishing House; 2020. Russian.
Kurtz JA, VanDusseldorp TA, Doyle JA, Otis JS. Taurine in sports and exercise. J Int Soc Sports Nutr. 2021;18(1):39. doi: 10.1186/S12970-021- 00438-0
Parkhomenko D, Belenichev I, Bukhtiyarova N, Kuchkovskyi O, Gorchakova N, Diachenko V, et al. Pharmacocorrection of Disturbances in the NO System in Experimental Chronic Generalized Periodontitis. Open Access Maced J Med Sci. 2023;11(A):47-52. doi: 10.3889/oam- jms.2023.10717
Drake KJ, Sidorov VY, McGuinness OP, Wasserman DH, Wikswo JP. Amino acids as metabolic substrates during cardiac ischemia. Exp Biol Med (Maywood). 2012;237(12):1369-78. doi: 10.1258/ebm.2012.012025
Belenichev IF, Chekman IS, Mazur IA, Gorchakova NA, Voloshin NA, Kucherenko LI. [Metabolitotropic drugs]. Zaporozhye: Pechatnyi Dom, 2007. Russian.
Belenichev IF, Aliyeva OG, Popazova OO, Bukhtiyarova NV. Involvement of heat shock proteins HSP70 in the mechanisms of endogenous neuroprotection: the prospect of using HSP70 modulators. Front Cell Neurosci. 2023;17:1-16. doi: 10.3389/FNCEL.2023.1131683
Maslennikov SO, Golovakha ML, Belenichev IF, Makyeyeva LV. Regenerative properties of polypropylene mesh coated with thiotriazoline and L-arginine. Biomed Pharmacol J. 2022;15(4). doi: 10.13005/BPJ/2537
Belenichev I, Gorbachova S, Pavlov S, Bukhtiyarova N, Puzyrenko A, Brek O. Neurochemical status of nitric oxide in the settings of the norm, ischemic event of central nervous system, and pharmacological intervention. Georgian Med News. 2021;315:169-76.
Belenichev I, Kucherenko L, Pavlov S, Bukhtiyarova N, Popazova O, Derevianko N, et al. Therapy of post-COVID-19 syndrome: improving the efficiency and safety of basic metabolic drug treatment with tiazotic acid (thiotriazoline). Pharmacia. 2022;69(2):509-16. doi: 10.3897/phar- macia.69.e82596
Zacharopoulos G, Sella F, Cohen Kadosh K, Hartwright C, Emir U, Cohen Kadosh R. Predicting learning and achievement using GABA and glutamate concentrations in human development. PLoS Biol. 2021;19(7): e3001325. doi: 10.1371/journal.pbio.3001325
Burke LM, Castell LM, Case DJ, Close GC, Costa RJS, Desbrow B, et al. International Association of Athletics Federations Consensus Statement 2019: Nutrition for athletics. Int J Sport Nutr Exerc Metab, 2019;29(2):73-84. doi: org/10.1123/ijsnem.2019-0065
Son H, Han SU, Lee K. 2,5-Diketo-D-Gluconate Hyperproducing Gluconobacter sphaericus SJF2-1 with Reporting Multiple Genes Encoding the Membrane-Associated Flavoprotein-Cytochrome c Complexed Dehydrogenases. Microorganisms. 2022;10(11):2130. doi: 10.3390/MICROOR- GANISMS10112130
Maughan RJ, Burke LM, Dvorak J, Larson-Meyer DE, Peeling P, Phillips SM, et al. IOC consensus statement: dietary supplements and the high-performance athlete. British J Sports Medicine. 2018;52(7):439-55. doi: 10.1136/ bjsports-2018-099027
Chen H, Wang Z., Wang Z, Dou J, Zhou C. Improving methionine and ATP availability by MET6 and SAM2 co-expression combined with sodium citrate feeding enhanced SAM accumulation in Saccharomyces cerevisiae. World J Microbiol Biotechnol, 2016;32(4):56. doi: 10.1007/s11274-016-2010-y
Hariharan S, Dharmaraj S. Selenium and selenoproteins: it’s role in regulation of inflammation. Inflammopharmacology. 2020;28(3):667-95. doi: 10.1007/s10787-020-00690-x
Gonzalez MJ, Miranda-Massari JR. Diet and stress. Psychiatr Clin North Am. 2014;37(4):579-89. doi: 10.1016/j.psc.2014.08.004
Renner C, Asperger A, Seyffarth A, Meixensberger J, Gebhardt R, Gaunitz F, Carnosine inhibits ATP production in cells from malignant glioma. Neurol Res. 2010;32(1):101-5. doi: 10.1179/016164109X12518779082237
Garthe I., Maughan RJ. Athletes and supplements: Prevalence and perspectives. Int J Sport Nutr Exerc Metab, 2018;28(2):126-38. doi: 10.1123/ ijsnem.2017-0429
Shen Y, Yang J, Li J, Shi X, Ouyang L, Tian Y, et al. Carnosine inhibits the proliferation of human gastric cancer SGC-7901 cells through both of the mitochondrial respiration and glycolysis pathways. PLoS One, 2014;9(8):e104632. doi: 10.1371/journal.pone.0104632
Varanoske AN, Hoffman JR, Church DD, Wang R, Baker KM, Dodd SJ, et al. Influence of skeletal muscle carnosine content on fatigue during repeated resistance exercise in recreationally active women. Nutrients. 2017;9(9):988. doi: 10.3390/nu9090988
Kalbe C, Metzger K, Gariépy C, Palin MF. Effect of muscle fibre types and carnosine levels on the expression of carnosine-related genes in pig skeletal muscle. Histochem Cell Biol. 2023;160:63-77. doi: 10.1007/ s00418-023-02193-6
Gunina LM. [A validity of the use of compositions on the basis of succinic acid in higher achievements sports]. Pedagog psychol med-biol probl phys train sports. 2012;5:50-4. Ukrainian. https://www.sportpedagogy.org.ua/html/ journal/2012-05/html-en/12glmhas.html
Rosenbloom C. Protein power: answering athletes’ questions about protein. Nutr Today. 2015;50(2):72-7. doi: 10.1097/NT.0000000000000083
Gleeson M. Immunological aspects of nutrition. Review. Immunol Cell Biol. 2016;94(2):117-23. doi: 10.1038/icb.2015.109
Alves PM, Nunes R, Zhang C, Maycock CD, Sonnewald U, Carrondo MJ et al. Metabolism of 3–(13)C–malate in primary cultures of mouse astrocytes. Dev Neurosci. 2000;22(5-6):456-62. doi: 10.1159/000017475
Van Remoortel H, De Buck E, Compernolle V, Deldicque L, Vandekerckhove P. The effect of a standard whole blood donation on oxygen uptake and exercise capacity: a systematic review and meta-analysis. Transfusion. 2017;57(2):451-62. doi: 10.1111/trf.13893
Stellingwerff T, Morton JP, Burke LM. A framework for periodized nutrition for athletics. Int J Sport Nutr Exerc Metab. 2019;29(2):141-51. doi: 10.1123/ ijsnem.2018-0305
Fry L, Madden AM, Fallaize R. An investigation into the nutritional composition and cost of gluten-free versus regular food products in the UK. J Hum Nutr Diet. 2018;31(1):108-20. doi: 10.1111/jhn.12502
Logan SW, Kipling Webster E, Getchell N, Pfeiffer KA, Robinson LE. Relationship between fundamental motor skill competence and physical activity during childhood and adolescence: A systematic review. Kinesiol Rev. 2015;4(4):416-26. doi: 10.1123/kr.2013-0012
Van Loon LJ, Tipton KD. Concluding remarks: nutritional strategies to support the adaptive response to prolonged exercise training. Nestle Nutr Inst Workshop Ser. 2013;75:135-41. doi: 10.1159/000345862
Gretchen V, Heather R. Position of the Academy of Nutrition and Dietetics: Dietary Fatty Acids for Healthy Adults Academy of Nutrition and Dietetics. J Acad Nutr Diet. 2014;114(1):136-53. doi: 10.1016/J.JAND.2013.11.001
