Approval of a comprehensive psychosocial rehabilitation program for patients with negative symptoms in schizophrenia




psychosocial rehabilitation, negative symptoms of schizophrenia, compliance, social functioning, patients with schizophrenia


The aim of the work is to develop and evaluate the effectiveness of a comprehensive program of psychosocial rehabilitation of patients with negative symptoms in schizophrenia.

Materials and methods. The study involved 168 patients with negative symptoms of schizophrenia: 94 patients who underwent a comprehensive psychosocial rehabilitation program (main group) and 74 patients who underwent a course of therapy according to the traditional scheme (control group). The criteria that evaluated the effectiveness of a comprehensive program of psychosocial rehabilitation in patients with negative symptoms in schizophrenia were: clinical dynamics of negative disorders, the degree of improvement/deterioration of compliance and social functioning, and the degree of restoration of basic life functions. Psychometric (Social Avoidance and Distress Scale (SADS), Personal and Social Functioning (PSP), Level of Compliance questionnaire, and the Severity of Negative Symptoms (SANS)) and statistical research methods were used to assess effectiveness.

Results. The proposed scheme of a complex program of psychosocial rehabilitation is based on the principles of a complex, individually oriented and differentiated approach, and its targets are defined as clinical manifestations of negative symptoms in schizophrenia, impaired social adaptation, communication skills, decreased motivational sphere, compliance and impaired social functioning. Rehabilitation is implemented in four stages: diagnostic, therapeutic, rehabilitation and preventive. The effectiveness of the proposed scheme of psychosocial rehabilitation of patients with negative symptoms in schizophrenia was proven, which consisted in a more pronounced reduction of clinical manifestations of abulia, anhedonia, inattention, reduction of distress and social avoidance, improvement of social functioning in the main spheres of life, and improvement of social and behavioral compliance.

Conclusions. The developed comprehensive program of psychosocial rehabilitation of patients with negative symptoms in schizophrenia has shown its effectiveness and can be used in psychocorrective measures aimed at treating patients with negative symptoms in schizophrenia.

Author Biography

Yu. A. Kushnir, Municipal Non-Profit Enterprise “Clinical Hospital “Psykhiatriia”, Kyiv, Ukraine

MD, PhD, Head of the Department


World Health Organization. World report on ageing and health [Internet]. WHO; 2015 [cited 2023 Jun 25]. 260 p. Available from:

Galderisi S, Kaiser S, Bitter I, Nordentoft M, Mucci A, Sabé M, et al. EPA guidance on treatment of negative symptoms in schizophrenia. Eur Psychiatry. 2021 Mar 17;64(1):e21. doi:

Kushnir YA. [Psychopathological characteristics of negative and positive symptoms in schizophrenia]. Prospects and innovations of science (“Pedagogy” Series, “Psychology” Series, “Medicine” Series). 2023;15(33):1148-59. Ukrainian. doi:

Capatina OO, Miclutia IV. Are negative symptoms in schizophrenia a distinct therapeutic target? Clujul Med. 2018;91(1):58-64. doi:

Karbalaee M, Jameie M, Amanollahi M, TaghaviZanjani F, Parsaei M, Basti FA, et al. Efficacy and safety of adjunctive therapy with fingolimod in patients with schizophrenia: A randomized, double-blind, placebo-controlled clinical trial. Schizophr Res. 2023;254:92-8. doi:

An der Heiden W, Leber A, Häfner H. Negative symptoms and their association with depressive symptoms in the long-term course of schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2016;266(5):387-96. doi:

Bucci P, Galderisi S. Categorizing and assessing negative symptoms. Curr Opin Psychiatry. 2017;30(3):201-8. doi:

Edgar CJ, Blaettler T, Bugarski-Kirola D, Le Scouiller S, Garibaldi GM, Marder SR. Reliability, validity and ability to detect change of the PANSS negative symptom factor score in outpatients with schizophrenia on select antipsychotics and with prominent negative or disorganized thought symptoms. Psychiatry Res. 2014;218(1-2):219-24. doi:

Ang MS, Rekhi G, Lee J. Associations of living arrangements with symptoms and functioning in schizophrenia. BMC Psychiatry. 2021;21(1):497. doi:

Galderisi S, Mucci A, Buchanan RW, Arango C. Negative symptoms of schizophrenia: new developments and unanswered research questions. Lancet Psychiatry. 2018;5(8):664-77. doi:

Correll CU. Using Patient-Centered Assessment in Schizophrenia Care: Defining Recovery and Discussing Concerns and Preferences. J Clin Psychiatry. 2020;81(3):MS19053BR2C. doi:

Maurus I, Hasan A, Schmitt A, Roeh A, Keeser D, Malchow B, et al. Aerobic endurance training to improve cognition and enhance recovery in schizophrenia: design and methodology of a multicenter randomized controlled trial. Eur Arch Psychiatry Clin Neurosci. 2021;271(2):315-24. doi:

Christensen TN, Wallstrøm IG, Stenager E, Bojesen AB, Gluud C, Nordentoft M, et al. Effects of Individual Placement and Support Supplemented With Cognitive Remediation and Work-Focused Social Skills Training for People With Severe Mental Illness: A Randomized Clinical Trial. JAMA Psychiatry. 2019;76(12):1232-40. doi:

Skokou M, Messinis L, Nasios G, Gourzis P, Dardiotis E. Cognitive Rehabilitation for Patients with Schizophrenia: A Narrative Review of Moderating Factors, Strategies, and Outcomes. Adv Exp Med Biol. 2023;1423:193-9. doi:

Wagner E, Kane JM, Correll CU, Howes O, Siskind D, Honer WG, et al. Clozapine Combination and Augmentation Strategies in Patients With Schizophrenia -Recommendations From an International Expert Survey Among the Treatment Response and Resistance in Psychosis (TRRIP) Working Group. Schizophr Bull. 2020;46(6):1459-70. doi:

Jia R, Liang D, Yu J, Lu G, Wang Z, Wu Z, et al. The effectiveness of adjunct music therapy for patients with schizophrenia: A meta-analysis. Psychiatry Res. 2020;293:113464. doi:

Vogel JS, van der Gaag M, Slofstra C, Knegtering H, Bruins J, Castelein S. The effect of mind-body and aerobic exercise on negative symptoms in schizophrenia: A meta-analysis. Psychiatry Res. 2019;279:295-305. doi:

Novo A, Fonsêca J, Barroso B, Guimarães M, Louro A, Fernandes H, et al. Virtual Reality Rehabilitation’s Impact on Negative Symptoms and Psychosocial Rehabilitation in Schizophrenia Spectrum Disorder: A Systematic Review. Healthcare (Basel). 2021;9(11):1429. doi:

Penadés R, Wykes T. Use of cognitive remediation to treat negative symptoms in schizophrenia: is it time yet? Br J Psychiatry. 2023;223(1):319-20. doi:

Chien WT, Mui JH, Cheung EF, Gray R. Effects of motivational interviewing-based adherence therapy for schizophrenia spectrum disorders: a randomized controlled trial. Trials. 2015;16:270. doi:



How to Cite

Kushnir, Y. A. (2024). Approval of a comprehensive psychosocial rehabilitation program for patients with negative symptoms in schizophrenia. Modern Medical Technology, 16(1), 46–53.