Changes of eye’s functions among patients with age-related macular degeneration during the use of vitamin D medications
DOI:
https://doi.org/10.14739/mmt.2024.3.306466Keywords:
age-related macular degeneration, vitamin D, visual acuity, contrast sensitivityAbstract
Aim. To increase the effectiveness of the treatment of age-related macular degeneration (AMD), dry form, in postmenopausal women by determining the level of serum vitamin D and correcting its deficiency.
Materials and methods. The study was conducted on the basis of the Department of Ophthalmology at Bogomolets National Medical University, was prospective, case-control, included 88 women (88 eyes) aged 72.0 ± 10.1 years, who were divided into 2 groups: control group – 20 patients (20 eyes) without AMD and study group – 68 patients (68 eyes) with AMD, dry form.
Results. Supplemental vitamin D did not significantly improve visual acuity, but slowed the deterioration of contrast sensitivity. Deficiency of vitamin D is associated with lower visual acuity, negatively affects contrast sensitivity, more strongly than its insufficiency. The results of the treatment in the AREDS-2 + vitamin D group after 12 months showed a probable double increase in the content of 25(OH)D in patients with AMD, dry form (p < 0.05). Visual acuity after 12 months decreased by 7.56 % (from 0.19 ± 0.06 to 0.20 ± 0.06) in women who took only AREDS-2 drugs, and by 6.78 % (from 0.18 ± 0.07 to 0.19 ± 0.08) in the group where vitamin D medications were additionally prescribed (p > 0.05). Logarithmic indicators of contrast sensitivity after treatment had a slight negative trend in both groups, decreased by 2.80 % in women in the AREDS-2 group, and by 2.25 % in women who additionally took vitamin D medications (p > 0.05).
Conclusions. Irreversible vision loss is a global problem with both medical and socioeconomic consequences. Age-related macular degeneration is one of the main diseases that lead to blindness, especially in people over 50 years old. Additional prescription of vitamin D to AREDS-2 may be beneficial in slowing the progression of AMD. Further studies are needed to confirm these results.
References
World Health Organization. Blindness and vision impairment [Internet]. 2023 [cited 2024 Sep 2]. Available from: https://www.who.int/news-room/fact-sheets/detail/blindness-and-visual-impairment
World Health Organization. World report on vision [Internet]. 2019. Available from: https://www.who.int/docs/default-source/documents/publications/world-vision-report-accessible.pdf
Chaudhuri M, Hassan Y, Bakka Vemana PP, Bellary Pattanashetty MS, Abdin ZU, Siddiqui HF. Age-Related Macular Degeneration: An Exponentially Emerging Imminent Threat of Visual Impairment and Irreversible Blindness. Cureus. 2023;15(5):e39624. doi: https://doi.org/https://doi.org/10.7759/cureus.39624
Li JQ, Welchowski T, Schmid M, Mauschitz MM, Holz FG, Finger RP. Prevalence and incidence of age-related macular degeneration in Europe: a systematic review and meta-analysis. Br J Ophthalmol. 2020;104(8):1077-84. doi: https://doi.org/https://doi.org/10.1136/bjophthalmol-2019-314422
Colijn JM, Buitendijk GH, Prokofyeva E, Alves D, Cachulo ML, Khawaja AP et al. Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future. Ophthalmology. 2017;124(12):1753-63. doi: https://doi.org/https://doi.org/10.1016/j.ophtha.2017.05.035
National Institute for Health and Care Excellence. Age-related macular degeneration. NICE guideline [NG82]. 2018. Available from: https://www.nice.org.uk/guidance/ng82
Komarova TM, Vitovska OP, Komisarenko JI, Kohan VM. Age-related macular degeneration – current state of the problem and prophylaxis methods. Wiad Lek. 2021;74(3 cz 2):767-72. doi: https://doi.org/https://doi.org/10.36740/WLek202103238
Komarova TM, Vitovska OP, Komisarenko YI, Scholtz SK. Vitamin D level and its link with visual acuity and contrast sensitivity in patients with age-related macular degeneration. Wiad Lek. 2023;76(5 pt 2):1173-8. doi: https://doi.org/https://doi.org/10.36740/WLek202305206
Kan E, Kan EK, Yücel ÖE. The Possible Link Between Vitamin D Levels and Exudative Age-related Macular Degeneration. Oman Med J. 2020;35(1):e83. doi: https://doi.org/https://doi.org/10.5001/omj.2020.01
Kabataş N, Doğan AŞ, Yılmaz M, Kabataş EU, Biçer T, Çalışkan S, et al. Association between age-related macular degeneration and 25(OH) vitamin D levels in the Turkish population. Arq Bras Oftalmol. 2022;85(1):7-12. doi: https://doi.org/https://doi.org/10.5935/0004-2749.20220002
Mahgoub MY, Abou Ghanima AT, Elmohamady MN, Abdul Basset S. Age-Related Macular Degeneration in Primary Osteoarthritis Egyptian Patients. Open Access Rheumatol. 2020;12:35-40. doi: https://doi.org/https://doi.org/10.2147/OARRR.S244838
Millen AE, Nie J, Mares JA, Lutsey PL, LaMonte MJ, Meuer SM, et al. Serum 25-Hydroxyvitamin D Concentrations and Incidence of Age-Related Macular Degeneration: The Atherosclerosis Risk in Communities Study. Invest Ophthalmol Vis Sci. 2019;60(5):1362-71. doi: https://doi.org/https://doi.org/10.1167/iovs.18-25945
Christen WG, Cook NR, Manson JE, Buring JE, Chasman DI, Lee IM, Bubes V, et al. Effect of Vitamin D and ω-3 Fatty Acid Supplementation on Risk of Age-Related Macular Degeneration: An Ancillary Study of the VITAL Randomized Clinical Trial. JAMA Ophthalmol. 2020;138(12):1280-9. doi: https://doi.org/https://doi.org/10.1001/jamaophthalmol.2020.4409
Sizar O, Khare S, Goyal A, Givler A. Vitamin D Deficiency. In: StatPearls. Treasure Island (FL): StatPearls Publishing; July 17, 2023.
Płudowski P, Kos-Kudła B, Walczak M, Fal A, Zozulińska-Ziółkiewicz D, Sieroszewski P, et al. Guidelines for Preventing and Treating Vitamin D Deficiency: A 2023 Update in Poland. Nutrients. 2023;15(3):695. doi: https://doi.org/https://doi.org/10.3390/nu15030695
Povoroznyuk VV, Grigorieva NV. Menopause and osteoporosis. Reproductive endocrinology. 2012;2(4):40-7. doi: https://doi.org/https://doi.org/10.18370/2309-4117.2012.4.40-47
Aribi M, Mennechet FJ, Touil-Boukoffa C. Editorial: The role of vitamin D as an immunomodulator. Front Immunol. 2023;14:1186635. doi: https://doi.org/https://doi.org/10.3389/fimmu.2023.1186635
Wong WL, Su X, Li X, Cheung CM, Klein R, Cheng CY, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health. 2014;2(2):e106-16. doi: https://doi.org/https://doi.org/10.1016/S2214-109X(13)70145-1
Age-Related Macular Degeneration: Facts & Figures. BrightFocus Foundation [Internet]. Brightfocus.org. 2023. Available from: https://www.brightfocus.org/macular/article/age-related-macular-facts-figures#
Cost of Vision Problems - Medical Costs by Disorder [Internet]. 2023. Available from: http://costofvision.preventblindness.org/costs/direct-costs/medical-costs-by-disorder
Klein R, Klein BE, Linton KL. Prevalence of Age-related Maculopathy: The Beaver Dam Eye Study. Ophthalmology. 2020;127(4S):S122-S132. doi: https://doi.org/https://doi.org/10.1016/j.ophtha.2020.01.033
Appell MB, Pejavar J, Pasupathy A, Rompicharla SV, Abbasi S, Malmberg K, Kolodziejski P, Ensign LM. Next generation therapeutics for retinal neurodegenerative diseases. J Control Release. 2024;367:708-36. doi: https://doi.org/https://doi.org/10.1016/j.jconrel.2024.01.063
Derzhavna sluzhba statystyky Ukrainy. Zaklady okhorony zdorovia ta Derzhavna sluzhba statystyky Ukrainy. Zakhvoriuvanist naselennia Ukrainy u 2017 rotsi. Kyiv; 2018 [cited 2024 Sep 2]. Ukrainian. Available from: https://ukrstat.gov.ua/druk/publicat/kat_u/2018/zb/06/zb_zoz_17.pdf
Luo BA, Gao F, Qin LL. The Association between Vitamin D Deficiency and Diabetic Retinopathy in Type 2 Diabetes: A Meta-Analysis of Observational Studies. Nutrients. 2017;9(3):307. doi: https://doi.org/https://doi.org/10.3390/nu9030307
Fritsche LG, Igl W, Bailey JN, Grassmann F, Sengupta S, Bragg-Gresham JL, et al. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nature Genetics. 2016;48(2):134-43. doi: https://doi.org/https://doi.org/10.1038/ng.3448
Agrón E, Mares J, Clemons TE, Swaroop A, Chew EY, Keenan TD; AREDS and AREDS2 Research Groups. Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2. Ophthalmology. 2021;128(3):425-42. doi: https://doi.org/https://doi.org/10.1016/j.ophtha.2020.08.018
Jung W, Han K, Kim B, Hwang S, Yoon JM, Park J, et al. Age-Related Macular Degeneration With Visual Disability Is Associated With Cardiovascular Disease Risk in the Korean Nationwide Cohort. J Am Heart Assoc. 2023;12(9):e028027. doi: https://doi.org/https://doi.org/10.1161/JAHA.122.028027
Flaxel CJ, Adelman RA, Bailey ST, Fawzi A, Lim JI, Vemulakonda GA, et al. Age-Related Macular Degeneration Preferred Practice Pattern®. Ophthalmology. 2020;127(1):P1-P65. doi: https://doi.org/10.1016/j.ophtha.2019.09.024
Parekh N, Chappell RJ, Millen AE, Albert DM, Mares JA. Association between vitamin D and age-related macular degeneration in the Third National Health and Nutrition Examination Survey, 1988 through 1994. Arch Ophthalmol. 2007;125(5):661-9. doi: https://doi.org/https://doi.org/10.1001/archopht.125.5.661
Ferreira A, Silva N, Furtado MJ, Carneiro Â, Lume M, Andrade JP. Serum vitamin D and age-related macular degeneration: Systematic review and meta-analysis. Surv Ophthalmol. 2021;66(2):183-97. doi: https://doi.org/https://doi.org/10.1016/j.survophthal.2020.07.003
Mousa A, Misso M, Teede H, Scragg R, de Courten B. Effect of vitamin D supplementation on inflammation: protocol for a systematic review. BMJ Open. 2016;6(4):e010804. doi: https://doi.org/https://doi.org/10.1136/bmjopen-2015-010804
Goldberg J, Flowerdew G, Smith E, Brody JA, Tso MO. Factors associated with age-related macular degeneration. An analysis of data from the first National Health and Nutrition Examination Survey. Am J Epidemiol. 1988;128:700-10. doi: https://doi.org/https://doi.org/10.1093/oxfordjournals.aje.a115023
Keenan TD, Agrón E, Domalpally A, Clemons TE, van Asten F, Wong WT, et al. Progression of Geographic Atrophy in Age-related Macular Degeneration: AREDS2 Report Number 16. Ophthalmology. 2018;125(12):1913-28. doi: https://doi.org/https://doi.org/10.1016/j.ophtha.2018.05.028
