Rare embryonal tumor of the central nervous system in newborns: case report and comparative clinical analysis

Authors

DOI:

https://doi.org/10.14739/mmt.2025.3.334181

Keywords:

embryonal neoplasms, central nervous system, newborn, pathology, autopsy

Abstract

Aim: to conduct a clinical and morphological analysis of a case of central nervous system (CNS) embryonic tumor not otherwise specified (NOS) and to determine its key pathogenetic features.

Materials and methods. A retrospective analysis was conducted of an autopsy case involving a deceased premature female neonate diagnosed with a CNS embryonal tumor, NOS. The material was obtained from the Division of Pathological Anatomy of the National Specialized Children’s Hospital “Ohmatdyt” of the Ministry of Health of Ukraine. The morphological diagnosis was established based on macroscopic and microscopic examination.

Results. The findings indicate an intrauterine origin of the CNS embryonal tumor NOS and the presence of characteristic morphological features that correlate with aggressive tumor behavior, including multiple necroses, hemorrhages, and pseudorosettes formations composed of poorly differentiated cells. The study emphasizes the importance of fetal magnetic resonance imaging in complex cases of prenatal hydrocephalus as a diagnostic tool and for determining further pregnancy management strategies.

Conclusions. The presented case highlights the need for an interdisciplinary approach to the diagnosis and care of newborns with CNS embryonal tumors and the creation of prognostic models for delivery outcomes in the presence of this pathology.

Author Biographies

A. S. Panina, Bogomolets National Medical University, Kyiv

MD student, Faculty of Medicine No. 1

P. V. Kuzyk, Bogomolets National Medical University, Kyiv

MD, PhD, Associate Professor of the Department of Pathological Anatomy; Pathologist at the National Research Center for Radiation Medicine, Hematology and Oncology, National Academy of Medical Sciences of Ukraine, Kyiv

T. V. Savchuk, Bogomolets National Medical University, Kyiv

MD, PhD, Associate Professor of the Department of Pathological Anatomy

V. A. Zhovnir, National Research Center for Radiation Medicine, Hematology and Oncology, National Academy of Medical Sciences of Ukraine, Kyiv

MD, PhD, DSc, Acting General Director

A. Zh. Sadykova, S.D. Asfendiyarov Kazakh National Medical University, Almaty

MD, PhD, Associate Professor of the Department of Childhood Diseases

References

International Agency for Research on Cancer. WHO classification of tumours of the central nervous system: Who classification of tumours. 5th ed. Who Classification of Tumours Editorial Board, editor. IARC; 2022. Available from: https://publications.iarc.fr/601

Rezaei N, Hanaei S, editors. Human brain and spinal cord tumors: From bench to bedside. Volume 2: The path to bedside management. Cham: Springer International Publishing; 2023. doi: https://doi.org/10.1007/978-3-031-23705-8

Santosh V, Rao S, Dasgupta A, Gupta T. Diagnosis and management of central nervous system embryonal tumors in the molecular era: A contemporary review. Int J Neurooncology. 2021;4(Suppl 1):S190-205. doi: https://doi.org/10.4103/ijno.ijno_427_21

Guidi M, Giunti L, Buccoliero AM, Santi M, Spacca B, De Masi S, et al. Use of high-dose chemotherapy in front-line therapy of infants aged less than 12 months treated for aggressive brain tumors. Front Pediatr. 2020;8. doi: https://doi.org/10.3389/fped.2020.00135

Kram D, Henderson J, Baig M, Chakraborty D, Gardner M, Biswas S, et al. Embryonal Tumors of the Central Nervous System in Children: The Era of Targeted Therapeutics. Bioengineering. 2018;5(4):78. doi: https://doi.org/10.3390/bioengineering5040078

Kwon SM, Kim JH, Kim YH, Hong SH, Cho YH, Kim CJ, et al. Clinical Implications of the Mitotic Index as a Predictive Factor for Malignant Transformation of Atypical Meningiomas. J Neurosurg Soc. 2022;65(2):297-306. doi: https://doi.org/10.3340/jkns.2021.0114

Pietsch T. [Neuropathology of medulloblastomas and other CNS embryonal tumors: Precision diagnostics through the integration of genetic markers]. Die Pathologie. 2019;40(2):140-7. German. doi: https://doi.org/10.1007/s00292-019-0580-9

Pickles JC, Hawkins C, Pietsch T, Jacques TS. CNS embryonal tumours: WHO 2016 and beyond. Neuropathol Appl Neurobiol. 2018;44(2):151-62. doi: https://doi.org/10.1111/nan.12443

Stensvold E, Krossnes BK, Lundar T, Due-Tønnessen BJ, Frič R, Due-Tønnessen P, et al. Outcome for children treated for medulloblastoma and supratentorial primitive neuroectodermal tumor (CNS-PNET) – a retrospective analysis spanning 40 years of treatment. Acta Oncol. 2017;56(5):698-705. doi: https://doi.org/10.1080/0284186x.2017.1301679

Hwang EI, Kool M, Burger PC, Capper D, Chavez L, Brabetz S, et al. Extensive Molecular and Clinical Heterogeneity in Patients With Histologically Diagnosed CNS-PNET Treated as a Single Entity: A Report From the Children’s Oncology Group Randomized ACNS0332 Trial. J Clin Oncol. 2018;36(34):3388-95. doi: https://doi.org/10.1200/jco.2017.76.4720

Ai R, Li J, Lai M, Cai L. RADT-27. Report of 9 Cases of Embryonal Tumors of The Central Nervous System with Multilayered Rosettes (ETMR). Neuro Oncol. 2024;26(Supplement_8):viii78. doi: https://doi.org/10.1093/neuonc/noae165.0311

Friedrich C, Warmuth-Metz M, von Bueren AO, Nowak J, Bison B, von Hoff K, et al. Primitive neuroectodermal tumors of the brainstem in children treated according to the HIT trials: clinical findings of a rare disease. J Neurosurg. 2015;15(3):227-35. doi: https://doi.org/10.3171/2014.9.peds14213

Bedei IA, Huisman TA, Whitehead W, Axt-Fliedner R, Belfort M, Sanz Cortes MS. Fetal Brain Tumors, a Challenge in Prenatal Diagnosis, Counselling, and Therapy. J Clin Med. 2022;12(1):58. doi: https://doi.org/10.3390/jcm12010058

Cambruzzi E, Pêgas KL, Nascimento GB, da Silva JN, Zandoná NB, Medeiros MS. Autopsy report and review of the 2016 WHO classification of congenital supratentorial embryonal tumors, not otherwise specified. Interdiscip Neurosurg. 2021;23:100913. doi: https://doi.org/10.1016/j.inat.2020.100913

Kapoor R, Bansal A, Aggarwal AK, Aggarwal A, Chaddha V, Kapoor S. A Rare Aggressive Fetal Intracranial Tumor. J Fetal Med. 2015;2(2):91-5. doi: https://doi.org/10.1007/s40556-015-0046-y

Kim SY, Tang M, Chih SY, Sallavanti J, Gao Y, Qiu Z, et al. Involvement of p38 MAPK and MAPKAPK2 in promoting cell death and the inflammatory response to ischemic stress associated with necrotic glioblastoma. Cell Death Amp Dis. 2025;16(1). doi: https://doi.org/10.1038/s41419-025-07335-3

Yee PP, Li W. Tumor necrosis: A synergistic consequence of metabolic stress and inflammation. BioEssays. 2021;43(7):2100029. doi: https://doi.org/10.1002/bies.202100029

Karsch-Bluman A, Benny O. Necrosis in the Tumor Microenvironment and Its Role in Cancer Recurrence. In: Birbrair A, editor. Tumor Microenvironment. Advances in Experimental Medicine and Biology. Cham: Springer; 2020. doi: https://doi.org/10.1007/978-3-030-35727-6_6

Al Shoufy M, Kafa G, Ibrahim B, Ibrahem H, Dakour A, Haidar A, et al. Exploring neonatal brain tumors: a narrative review about epidemiology, classification, and management. Ann Med Amp Surg. 2025;87(5):2838-46. doi: https://doi.org/10.1097/ms9.0000000000003229

Tully HM, Dobyns WB. Infantile hydrocephalus: a review of epidemiology, classification and causes. Eur J Med Genet. 2014 Aug;57(8):359-68. doi: https://doi.org/10.1016/j.ejmg.2014.06.002

Toniutti M, Sasso AL, Carai A, Colafati GS, Piccirilli E, Del Baldo G, et al. Central nervous system tumours in neonates: what should the neonatologist know? Eur J Pediatr. 2024;183(4):1485-97. doi: https://doi.org/10.1007/s00431-023-05404-3

Khairudin D, Alfirevic Z, Mone F, Navaratnam K. Non‐immune hydrops fetalis: a practical guide for obstetricians. Obstet Gynaecol. 2023;25(2):110-20. doi: https://doi.org/10.1111/tog.12862

Albar OH, Maghfuri LM, Alhadri HY, Albahli FH, Omairah MH, Albahli HM, et al. Innovations in maternal-fetal medicine and neonatology: A multidisciplinary approach to enhancing care for high-risk pregnancies and premature infants. J Ecohumanism. 2024;3(8):12904-14. doi: https://doi.org/10.62754/joe.v3i8.6155

Malachynska M, Kuzyk P, Diegtiar O. Promoting healthy births and reducing infant mortality through national health system. Int J Health Sci. 2021;5(3):449-60. doi: https://doi.org/10.53730/ijhs.v5n3.1905

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Published

2025-09-25

How to Cite

Panina, A. S., Kuzyk, P. V., Savchuk, T. V., Zhovnir, V. A., & Sadykova, A. Z. (2025). Rare embryonal tumor of the central nervous system in newborns: case report and comparative clinical analysis. Modern Medical Technology, 17(3), 224–229. https://doi.org/10.14739/mmt.2025.3.334181