One of the main problems in reconstructive surgery is the closure of large gunshot wounds. Autodermoplasty is considered the gold standard. Given the injury mechanism, the duration of wound surface preparation is quite long. The use of platelet-rich plasma (PRP) therapy can accelerate the growth of granulations in wounds and shorten the duration of preparing patients for autodermoplasty.

The aim of the work is to determine the effectiveness of PRP therapy as a stage of preparation of isolated gunshot soft tissues wounds of the limbs for autodermoplasty.

Materials and methods. The study included 80 (100.0 %) patients with isolated soft tissue gunshot wounds of the limbs who were delivered to the R3 phase of evacuation. All patients were divided into two groups. The main group included 40 (50.0 %) patients who received platelet-enriched autoplasma injections in the preoperative period as a stage of preparation for autodermoplasty. The comparison group included 40 (50.0 %) patients who were treated according to the standard protocol and underwent autodermoplasty.

Results. Early granulations were found in the main group on day 10.4 (9.5; 13.4), in the comparison group on day 15.0 (12.5; 22.7), U = 397.0, p = 0.0012. The predominant area of the wound defect was covered by granulation in the main group on average on day 15.6 (12.9; 17.7) after hospitalization, in the comparison group on day 22.0 (14.0; 27.5), U = 324.0, p = 0.0011. Postoperative complications were found in the main group in 3 (7.5 %) patients, in the comparison group in 10 (25.0 %) patients, U = 660.0, p = 0.0357. Repeated surgical interventions were performed in 1 (2.5 %) patient in the main group and in 6 (15.0 %) patients in the control group.

Conclusions. The use of PRP therapy as a stage of wound preparation for autodermoplasty shortens the preoperative period. In the main group, autodermoplasty was performed on day 16.7 (13.4; 19.6), in the comparison group on day 25.8 (16.7; 29.6), U = 374.0, p = 0.0006. The period of patients’ hospital stay was also reduced. In the main group, the length of stay was 27.5 (24.5; 29.7) days, in the comparison group it was 35.4 (32.0; 38.2) days, U = 356.0, p = 0.0001.